Side effects of oral ivermectin are rare and usually minor. Single dose of 150mcg/kg (may be repeated every 3 to 12 months)ĭose of 200mcg/kg repeated in 7 to 14 days It is rapidly absorbed from the gut and metabolised in the liver. The tablets can be crushed, for example to be given via a percutaneous endoscopic gastrostomy (PEG) tube. Ivermectin is taken as a single dose with a glass of water. However, this is usually not significant enough to alter coagulation parameters such as the prothrombin ratio. There have been some reports of a mild anti- coagulation effect. It therefore does not require dose adjustment for people with renal failure. It is almost exclusively excreted in faeces with minimal clearance by the kidneys. Ivermectin is primarily metabolised in the liver by CYP450-3A47 and has a plasma half life of 16 hours. Oral ivermectin appears to be a safe medication.
Ivermectin cream has been shown to reduce papulopustular rosacea, which is thought to be due to its effects on demodex mites and its anti- inflammatory action.Ī 2021 Cochrane Review has not found sufficient evidence to support the use of ivermectin for preventing or treating COVID-19. Ivermectin can also be used to control demodicosis. In treatment of scabies its use may be appropriate in selected cases where topical therapy is impractical or has failed and is particularly useful in cases of crusted scabies (also called ‘Norwegian’ scabies). It has FDA approval for the treatment of strongyloides and onchocerciasis in the United States, other use is termed ‘off label’. Ivermectin has been used extensively as part of the World Health Organisation's Onchocerciasis Eradication Program. Parasitic worms including: onchocerciasis (river blindness), strongyloides, cutaneous larva migrans and filiariasis such as onchocerciasis.Ivermectin is effective against infections with: Ivermectin cream (Soolantra™) was approved by the FDA in December 2014 but is not yet readily available. In New Zealand, ivermectin is available in 3 mg tablets (Stromectol™). Ivermectin is a macrocyclic lactone medicine used to treat parasitic infections.
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